ABSTRACT
<p><b>OBJECTIVE</b>To observe the clinical efficacy of Flos Magnoliae volatile oil nano-liposome nasal drops (FMO) in treating pediatric allergic rhinitis (PAR).</p><p><b>METHODS</b>Adopting parallel controlled method, the 191 patients with PAR were randomized into two groups. The observation group was treated with FMO, and the control group with Cetirizine. The clinical efficacy, main symptoms, signs, syndromes scores of Chinese medicine, and peripheral eosinophil (EOS) count were observed after 3-week treatment.</p><p><b>RESULTS</b>In the observation group, the total effective rate was 94.84%, which was higher than that in the control group (78.72%); the effective rate on alleviating main symptoms (sneezing, nasal obstruction), signs (nasal mucosa edema, pallor) and the EOS count were significantly lowered, all were better than those in the control group (P <0.05).</p><p><b>CONCLUSION</b>FMO has some positive effects on PAR, it might be realized by lowering the peripheral EOS.</p>
Subject(s)
Child , Child, Preschool , Female , Humans , Male , Drugs, Chinese Herbal , Eosinophils , Liposomes , Therapeutic Uses , Oils, Volatile , Therapeutic Uses , Phytotherapy , Rhinitis, Allergic, Perennial , Drug Therapy , Rhinitis, Allergic, Seasonal , Drug Therapy , Treatment OutcomeABSTRACT
<p><b>OBJECTIVE</b>To assess the effect and adverse reaction of Qufeng Zhidong Recipe (QZR) in treating children's tic disorder (TD).</p><p><b>METHODS</b>With multicenter randomized parallel open-controlled method adopted, the patients enrolled were assigned to two groups, 41 cases in the Chinese medicine (CM) group and 40 in the Western medicine (WM) group. They were treated by QZR and haloperidol plus trihexyphenidyl respectively for 12 weeks as one course. In total, two courses of treatment were given. The curative effect and adverse reactions were evaluated by scoring with Yale Global Tic Severity Scale (YGTSS), Traditional Chinese Medicine Syndrome Scale (TCMSS), and Treatment Emergent Symptom Scale (TESS), as well as results of laboratory examinations.</p><p><b>RESULTS</b>After one course of treatment, the markedly effective rate in the CM and the WM group was 14.6% and 17.5%, respectively, and the total effective rate 43.9% and 47.5%, respectively, which showed insignificant difference between groups (P>0.05). However, after two courses of treatment, markedly effective rate in them was 73.2% and 7.5%, and the total effective rate was 100.0% and 57.5%, both showing significant differences between groups (P<0.05). Besides, the adverse reactions occurred in the CM group was less than that in the WM group obviously.</p><p><b>CONCLUSION</b>QZR has definite curative effect with no apparent adverse reaction in treating TD, and it can obviously improve the symptoms and signs and upgrade the quality of life and learning capacities in such patients.</p>
Subject(s)
Child , Child, Preschool , Female , Humans , Male , Antiparkinson Agents , Antipsychotic Agents , Cookbooks as Topic , Drug Therapy, Combination , Drugs, Chinese Herbal , Therapeutic Uses , Haloperidol , Tic Disorders , Drug Therapy , Treatment Outcome , Trihexyphenidyl , Western WorldABSTRACT
<p><b>OBJECTIVE</b>To investigate the effect of Lishi No.5 formula on the growth of human neuroblastoma cell line SY5Y and find out the most effective drug dose.</p><p><b>METHOD</b>SY5Y cells were administrated by Lishi No.5 formula in different concentration. MTT metabolic rate was measured as the cell survival rate, then the dose-effect curve was made. LDH leakage rate, axonal length and area of cell body were used as the indicators.</p><p><b>RESULT</b>In 0.125-0.75 g x L(-1) Lishi No. 5 formula could increase the cell survival rate and MTT metabolic rate, decreased LDH leakage rate, and enhance axonal length and area of cell body, compared with control group.</p><p><b>CONCLUSION</b>Lishi No.5 formula has the neurotrophic effect and can induce the survival of neuron.</p>
Subject(s)
Humans , Cell Line, Tumor , Cell Proliferation , Cell Survival , Dose-Response Relationship, Drug , Drug Combinations , Drugs, Chinese Herbal , Pharmacology , L-Lactate Dehydrogenase , Metabolism , Neuroblastoma , Metabolism , Pathology , Plants, Medicinal , ChemistryABSTRACT
<p><b>OBJECTIVE</b>To observe the effect of Jiunaoyizhi capsul on the signal transduction pathway of SY5Y cell lines and explore the mechanism of the function of the capsul's enhancing neuronal growth.</p><p><b>METHOD</b>Human neuroblastoma was used as cell models and they were divided into control group and experimental group. Supernatant of cell lysate was taken and immunoprecipitation was done with antibodies to proteins related to signal transduction pathway, and the immunoprecipitates were analyzed by Western blotting.</p><p><b>RESULT</b>After treatment with Jiunaoyizhi capsul, expression of Akt/PKB, CREB, P-CREB was clearly increased and expression of cytochrome C decreased more than the control group.</p><p><b>CONCLUSION</b>Jiunaoyizhi capsul can promote expression of some proteins related with signal transduction pathway in SY5Y cell lines. Mechanism of Jiunaoyizhi capsul's enhancing neuronal growth is relevant to expression of some proteins in signal transduction pathway.</p>
Subject(s)
Humans , Cell Line, Tumor , Cell Proliferation , Cyclic AMP Response Element-Binding Protein , Metabolism , Cytochromes c , Metabolism , Drug Combinations , Drugs, Chinese Herbal , Pharmacology , Neuroblastoma , Metabolism , Pathology , Neurons , Plants, Medicinal , Chemistry , Signal TransductionABSTRACT
OBJECTIVE：To observe the antisepsis and anti-inflammatory action of Xiaoyan tablet.METHODS:Using physiological saline as control,the antiinflammatory effiects on the oncotic extent of the ear auricle of the mouse caused by xylene and swollen toes of rat caused by rat mucllago. and the antibiotic effects on staphylococcus aureus,beta hemolytic streptococcus,pneumococcus,bacillus influenzae were studied.RESULTS:The inflammatory effects of taking medicine group was dramatic compared with physiological saline group(P＜0.01).Its antisepsis action is equivalent to oral liquor of double coptis chinensis.CONCLUSION:The antisepsis and anti-inflammatory action of Xiaoyan tablet is better.